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Invitrogen
Agrin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-109369
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
3.99 mg/mL
Amount
399 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TCPERALERR EEEANVVLTG TVEEILNVDP VQHTYSCKVR VWRYLKGKDL VARESLLDGG NKVVISGFGD PLICDNQVST GDTRIFFVNP APPYLWPAHK NELMLNSSLM RITLRNLEEV EFCVEDKPGT HFTPVPPTPP DACRGMLCGF GAVCEPNAEG PGRASCVCKK SPCPSVVAPV CGSDASTYSN ECELQRAQCS QQRRIRLLSR GPCGSRDPCS NVTCSFGSTC ARSADGLTAS CLCPATCRGA PEGTVCGSDG ADYPGECQLL RRACARQENV FKKFDGPCDP CQGALPDPSR SCRVNPRTRR PEMLLRPESC P
Target Information
Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation. Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants have been identified which arise from alternative mRNA splicings. Agrin splice forms having inserts at two sites in the carboxy terminus designated "y" and "z" display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly. Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention. Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation. Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: agrin proteoglycan; extracellular matrix proteoglycan; laminin-binding domain; RP23-139J18.2; synaptic basal lamina component; unnamed protein product
Gene Aliases: AGR; AGRIN; CMS8; CMSPPD; nmf380
UniProt ID: (Human) O00468, (Rat) P25304, (Mouse) A2ASQ1
Entrez Gene ID: (Human) 375790, (Rat) 25592, (Mouse) 11603
dystroglycan binding
structural constituent of cytoskeleton
extracellular matrix structural constituent
calcium ion binding
protein binding
transmembrane receptor protein tyrosine kinase activator activity
receptor activator activity
acetylcholine receptor regulator activity
sialic acid binding
chondroitin sulfate binding
laminin binding
heparan sulfate proteoglycan binding
receptor agonist activity
BMP binding
ATPase inhibitor activity
ion channel binding
transforming growth factor beta binding
transporter inhibitor activity
chondrocyte differentiation
cytoskeleton organization
signal transduction
cell surface receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
chemical synaptic transmission
nervous system development
neuromuscular junction development
receptor clustering
clustering of voltage-gated sodium channels
positive regulation of synaptic growth at neuromuscular junction
positive regulation of transcription from RNA polymerase II promoter
filopodium assembly
animal organ development
synapse organization
membrane organization
synaptic signaling
plasma membrane organization
enzyme linked receptor protein signaling pathway
synapse assembly
circadian rhythm
protein transport
positive regulation of Rac protein signal transduction
positive regulation of neuron apoptotic process
regulation of synapse organization
regulation of cardiac muscle contraction
regulation of synaptic activity
regulation of microtubule cytoskeleton organization
skeletal muscle acetylcholine-gated channel clustering
regulation of cardiac muscle cell membrane potential
regulation of axon guidance
negative regulation of sodium ion export from cell
positive regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein binding
positive regulation of filopodium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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