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Invitrogen

Phospho-FOXO3A (Ser294) Polyclonal Antibody

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Phospho-FOXO3A (Ser294) Polyclonal Antibody

Product Details

PA5-110123

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S294 of human FOXO3A (NP_0014461)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.37 mg/mL

Amount

337 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2855534

Product Specific Information

Immunogen sequence: PGSPT

Target Information

USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: forkhead box O3A; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO3A-; member of FKHR-subclass forkhead/winged helix family; unnamed protein product

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Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3A

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UniProt ID: (Human) O43524, (Mouse) Q9WVH4

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Entrez Gene ID: (Human) 2309, (Mouse) 56484, (Rat) 294515

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding protein kinase binding chromatin DNA binding mitochondrial RNA polymerase binding promoter specificity activity sequence-specific DNA binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from mitochondrial promoter regulation of translation phagocytosis response to xenobiotic stimulus gene expression positive regulation of autophagy positive regulation of muscle atrophy DNA damage response, signal transduction by p53 class mediator negative regulation of cell migration response to nutrient levels tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress cellular response to glucose starvation glucose homeostasis response to starvation positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of regulatory T cell differentiation positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter brain morphogenesis response to fatty acid cellular response to glucose stimulus cellular response to corticosterone stimulus response to dexamethasone negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus response to water-immersion restraint stress regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process
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