Search
Invitrogen
PKP2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation'] || 'Additional Information'}}:
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
FIGURE: 1 / 1
PKP2 Antibody (PA5-110175) in WB
Western blot analysis of PKP2 in extracts of various cell lines. Samples were incubated with PKP2 Polyclonal antibody (Product # PA5-110175) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-110175
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.27 mg/mL
Amount
27 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LPEKYSQNIY IQNRNIQTDN NKSIGCFGSR SRKVKEQYQD VPMPEEKSNP KGVEWLWHSI VIRMYLSLIA KSVRNYTQEA SLGALQNLTA GSGPMPTSVA QTVVQKESGL QHTRKMLHVG DPSVKKTAIS LLRNLSRNLS LQNEIAKETL PDLVSIIPDT VPSTDLLIET TASACYTLNN IIQNSYQNAR DLLNTGGIQK IMAISAGDAY ASNKASKAAS VLLYSLWAHT ELHHAYKKAQ FKKTDFVNSR TAKAYHSLKD
Target Information
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: desmosomal protein; K112N; desmosomal protein; Q62DfsX22; desmosomal protein; T816RfsX9; desmosomal protein; V587I; unnamed protein product
Gene Aliases: 1200008D14Rik; 1200012P04Rik; ARVD9; Pkp2l
UniProt ID: (Human) Q99959, (Mouse) Q9CQ73, (Rat) F1M7L9
Entrez Gene ID: (Human) 5318, (Mouse) 67451, (Rat) 287925
desmosome assembly
desmosome organization
cell-cell signaling
heart development
positive regulation of sodium ion transport
regulation of cell-substrate adhesion
intermediate filament bundle assembly
maintenance of organ identity
ventricular cardiac muscle tissue morphogenesis
protein localization to plasma membrane
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
cell-cell adhesion
regulation of ventricular cardiac muscle cell action potential
maintenance of protein localization at cell tip
regulation of substrate adhesion-dependent cell spreading
negative regulation of cell proliferation
gap junction assembly
negative regulation of cell migration
adherens junction maintenance
positive regulation of cell adhesion
lipid homeostasis
cardiac muscle cell action potential
regulation of bicellular tight junction assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support