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Invitrogen
NCK2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-112625
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Cytoplasmic protein NCK2 protein (1-380AA)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: growth factor receptor-bound protein 4; NCK adaptor protein 2; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein; SH2/SH3 adaptor protein NCK-beta; unnamed protein product
Gene Aliases: 4833426I10Rik; GRB4; Nck-2; NCKbeta
UniProt ID: (Human) O43639, (Mouse) O55033
Entrez Gene ID: (Human) 8440, (Mouse) 17974
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
signal transduction
signal complex assembly
epidermal growth factor receptor signaling pathway
negative regulation of cell proliferation
cell migration
positive regulation of actin filament polymerization
response to endoplasmic reticulum stress
regulation of translation initiation in response to endoplasmic reticulum stress
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
immunological synapse formation
actin filament organization
lamellipodium assembly
dendritic spine development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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