Search

  • Contáctenos
  • Orden Rápida

Invitrogen

PSEN2 Polyclonal Antibody

View all (22) PSEN2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
PSEN2 Polyclonal Antibody

Product Details

PA5-113786

Applications
Tested Dilution
Publications

Western Blot (WB)

0.2-1 µg/mL
-

Immunohistochemistry (IHC)

1:600
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the N terminal region of human PSEN2 (aa 101-150).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

50 µg

Purification

Affinity chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2884301

Product Specific Information

Immunogen sequence: VVVATIKSVR FYTEKNGQLI YTPFTEDTPS VGQRLLNSVL NTLIMISVIV

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Target Information

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: AD3LP; AD5; Alzheimer disease 3-like; Alzheimer disease 4; E5-1; Presenilin-2; PS-2; PSEN 2; STM-2; unnamed protein product

View more View less

Gene Aliases: AD3L; AD4; Ad4h; ALG-3; Alg3; CMD1V; PS-2; PS2; PSEN2; PSNL2; STM2

View more View less

UniProt ID: (Human) P49810, (Mouse) Q61144

View more View less

Entrez Gene ID: (Human) 5664, (Mouse) 19165

View more View less

Function(s)
protein binding peptidase activity hydrolase activity aspartic endopeptidase activity, intramembrane cleaving endopeptidase activity aspartic-type endopeptidase activity aspartic protease
Process(es)
response to hypoxia proteolysis membrane protein ectodomain proteolysis Notch signaling pathway Notch receptor processing protein processing beta-amyloid formation intracellular signal transduction amyloid precursor protein catabolic process calcium ion homeostasis regulation of calcium import into the mitochondrion mitochondrion-ER tethering negative regulation of transcription from RNA polymerase II promoter cell fate specification somitogenesis positive regulation of receptor recycling negative regulation of protein phosphorylation hair follicle development hematopoietic progenitor cell differentiation T cell activation involved in immune response myeloid leukocyte differentiation calcium ion transport negative regulation of epidermal growth factor-activated receptor activity regulation of epidermal growth factor-activated receptor activity learning or memory memory embryo development protein transport dorsal/ventral neural tube patterning embryonic limb morphogenesis forebrain development negative regulation of protein complex assembly negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis locomotion anagen positive regulation of apoptotic process positive regulation of catalytic activity regulation of protein binding skin morphogenesis cellular protein metabolic process regulation of synaptic plasticity lung alveolus development thymus development brain morphogenesis beta-amyloid metabolic process positive regulation of coagulation T cell receptor signaling pathway negative regulation of ubiquitin-protein transferase activity protein maturation cardiac muscle contraction negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support