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Invitrogen

HES5 Polyclonal Antibody

View all (12) HES5 antibodies

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Product Details

PA5-113930

Applications
Tested Dilution
Publications

Western Blot (WB)

0.2-1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the middle region of human HES5

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2884445

Product Specific Information

Immunogen sequence: AASDTQMKLL YHFQRPPAAP AAPAKEPKAP GAAPPPALSA KATAAAAAAH

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology: Cow: 93%; Dog: 100%; Guinea Pig: 85%; Human: 100%; Mouse: 88%; Rat: 93%

Target Information

Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma. Reports also suggest that HES5 is abundantly expressed in osteoarthritis along with Notch1 and Jagged1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; Notch pathway transcription factor; RP3-395M20.5; Transcription factor HES-5

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Gene Aliases: BHLHB38; HES5

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UniProt ID: (Human) Q5TA89

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Entrez Gene ID: (Human) 388585

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein dimerization activity sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter chondrocyte differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell adhesion Notch signaling pathway smoothened signaling pathway nervous system development brain development positive regulation of cell proliferation anterior/posterior pattern specification oligodendrocyte development telencephalon development glial cell fate commitment neural tube development central nervous system neuron differentiation central nervous system myelination cell differentiation neuron differentiation BMP signaling pathway positive regulation of BMP signaling pathway regulation of myelination auditory receptor cell differentiation camera-type eye development regulation of cell differentiation negative regulation of cell differentiation negative regulation of auditory receptor cell differentiation regulation of neuron differentiation negative regulation of neuron differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade cell maturation animal organ development positive regulation of smooth muscle cell proliferation astrocyte differentiation oligodendrocyte differentiation negative regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation system development regulation of epithelial cell proliferation regulation of neurogenesis cartilage development inner ear receptor stereocilium organization protein-containing complex assembly comma-shaped body morphogenesis S-shaped body morphogenesis specification of loop of Henle identity metanephric nephron tubule morphogenesis establishment of epithelial cell polarity neuronal stem cell population maintenance negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation negative regulation of inner ear receptor cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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