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Invitrogen
CYP2C19 Polyclonal Antibody
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FIGURE: 1 / 4
CYP2C19 Antibody (PA5-114368) in IHC (P)
Immunohistochemistry analysis of CYP2C19 in paraffin-embedded human liver cancer tissues. Antigen retrieval was performed with citrate buffer (pH6, 20 min). Samples were blocked with 10% goat serum and incubated in CYP2C19 polyclonal antibody (Product # PA5-114368) at a dilution of 1 µg/mL (overnight, 4°C), followed by biotinylated goat anti-rabbit IgG (30 min, 37°C) and Strepavidin-Biotin-Complex (SABC) wi... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-114368
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human Cytochrome p450 2C19/CYP2C19 (QNQQSEFTIENLVITAADLLGAGTETT).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL once reconstituted
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat liver tissue, rat liver tissue. IHC: rat liver tissue, human liver cancer tissue, mouse liver tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; cyto; cytochrome P-450 II C; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; cytochrome P450-11A; cytochrome P450-254C; fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; mephenytoin 4-hydroxylase; microsomal monooxygenase; P450-11A; P450-254C; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CPCJ; CYP2C; CYPIIC17; CYPIIC19; P450C2C; P450IIC19
UniProt ID: (Human) P33261
Entrez Gene ID: (Human) 1557
monooxygenase activity
iron ion binding
steroid hydroxylase activity
arachidonic acid 14,15-epoxygenase activity
arachidonic acid 11,12-epoxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
oxygen binding
enzyme binding
heme binding
(R)-limonene 6-monooxygenase activity
arachidonate 8,9-epoxygenase activity
long-chain fatty acid omega-1 hydroxylase activity
fatty acid omega-1 hydroxylase activity
long-chain fatty acid metabolic process
fatty acid metabolic process
terpenoid metabolic process
xenobiotic metabolic process
steroid metabolic process
monoterpenoid metabolic process
epoxygenase P450 pathway
monocarboxylic acid metabolic process
xenobiotic catabolic process
omega-hydroxylase P450 pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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