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Invitrogen
alpha-2c Adrenergic Receptor Polyclonal Antibody
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FIGURE: 1 / 2
alpha-2c Adrenergic Receptor Antibody (PA5-114828) in ICC/IF
Immunocytochemistry analysis of alpha-2c Adrenergic Receptor in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114828) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 8... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-114828
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADRA2C(Accession P18825), corresponding to amino acid residues S349-F399.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Adrenergic Receptor alpha -2C.
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adra 2c; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; Alpha 2CAR; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; kidney alpha-2-adrenergic receptor; subtype alpha2-C4
Gene Aliases: [a]2C; Adra-2c; ADRA2L2; ADRA2RL2; ADRARL2; alpha2-C4; alpha2C; ALPHA2CAR
UniProt ID: (Human) P18825, (Mouse) Q01337, (Rat) P22086
Entrez Gene ID: (Human) 152, (Mouse) 11553, (Rat) 24175
regulation of smooth muscle contraction
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
negative regulation of epinephrine secretion
positive regulation of MAPK cascade
positive regulation of neuron differentiation
negative regulation of insulin secretion
positive regulation of protein kinase B signaling
adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
female pregnancy
positive regulation of vasoconstriction
negative regulation of uterine smooth muscle contraction
regulation of uterine smooth muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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