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Invitrogen
FBXO7 Polyclonal Antibody
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FIGURE: 1 / 9
FBXO7 Antibody (PA5-115219) in ICC/IF
Immunocytochemistry analysis of FBXO7 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115219). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115219
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FBXO7(Accession Q9Y3I1), corresponding to amino acid residues P416-P466.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FBXO7.
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686B08113; FBXO7; unnamed protein product
Gene Aliases: 2410015K21Rik; A230052G17Rik; FBX; FBX07; FBX7; PARK15; PKPS
UniProt ID: (Human) Q9Y3I1, (Rat) Q68FS3, (Mouse) Q3U7U3
Entrez Gene ID: (Human) 25793, (Rat) 366854, (Mouse) 69754
mitophagy
ubiquitin-dependent protein catabolic process
regulation of neuron projection development
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of protein stability
regulation of locomotion
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
protein localization to mitochondrion
protein K48-linked ubiquitination
positive regulation of mitophagy
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of mitophagy
biological_process
negative regulation of neuron apoptotic process
negative regulation of lymphocyte differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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