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Invitrogen
FRS2 Polyclonal Antibody
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FIGURE: 1 / 2
FRS2 Antibody (PA5-115253) in ICC/IF
Immunocytochemistry analysis of FRS2 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115253) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115253
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FRS2(Accession Q8WU20), corresponding to amino acid residues S410-L460.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FRS2.
Target Information
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; SNT2; suc1-associated neurotrophic factor target 1; unnamed protein product
Gene Aliases: C330018A15Rik; FRS1A; FRS2-alpha; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
UniProt ID: (Human) Q8WU20, (Mouse) Q8C180
Entrez Gene ID: (Human) 10818, (Mouse) 327826
gastrulation with mouth forming second
organ induction
lens development in camera-type eye
ventricular septum development
transmembrane receptor protein tyrosine kinase signaling pathway
neuroblast proliferation
fibroblast growth factor receptor signaling pathway
anterior/posterior axis specification, embryo
forebrain development
regulation of apoptotic process
positive regulation of MAPK cascade
cellular response to fibroblast growth factor stimulus
optic placode formation involved in camera-type eye formation
regulation of epithelial cell proliferation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
lens fiber cell development
regulation of ERK1 and ERK2 cascade
positive regulation of vascular smooth muscle cell proliferation
negative regulation of cardiac muscle cell differentiation
transmembrane receptor protein tyrosine phosphatase signaling pathway
G-protein coupled receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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