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Invitrogen
GCKR Polyclonal Antibody
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FIGURE: 1 / 3
GCKR Antibody (PA5-115274) in IHC (P)
Immunohistochemistry analysis of GCKR in human esophageal cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115274) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115274
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GCKR(Accession Q14397), corresponding to amino acid residues G207-S257.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total GCKR.
Target Information
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GKRP; glucokinase (hexokinase 4) regulator; Glucokinase regulator; Glucokinase regulatory protein; hexokinase 4; hexokinase 4 regulator; unnamed protein product
Gene Aliases: FGQTL5; GCKR; GKRP; GLRE
UniProt ID: (Human) Q14397, (Rat) Q07071, (Mouse) Q91X44
Entrez Gene ID: (Human) 2646, (Rat) 25658, (Mouse) 231103
cellular glucose homeostasis
protein import into nucleus
response to glucose
response to fructose
negative regulation of glucokinase activity
protein localization to nucleus
urate metabolic process
triglyceride homeostasis
carbohydrate derivative metabolic process
protein import into nucleus, translocation
glucose metabolic process
positive regulation of glucokinase activity
negative regulation of catalytic activity
detection of glucose
carbohydrate metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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