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Invitrogen
GZMB/GZMH Polyclonal Antibody
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FIGURE: 1 / 6
GZMB/GZMH Antibody (PA5-115323) in IHC (P)
Immunohistochemistry analysis of GZMB/GZMH in human normal tissues adjacent to pancreatic cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115323) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115323
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GZMB(Accession P10144), corresponding to amino acid residues M1-G50.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Granzyme B/H.
Target Information
GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; cathepsin G-like 1; cathepsin G-like 2, protein h-CCPX; CGL-2; CGL2; CTLA1; cytotoxic cell protease 1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; cytotoxin serine protease-C; cytotoxin serine protease-C precursor; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme-like protein 1; granzyme-like protein I; Gzmb; GZMH; GZMH/GZMB; human lymphocyte protein; natural killer cell protease 1; proteolytic serine esterase; serine protease; serine protease-like protein precursor; T-cell serine protease 1-3E; T-cell specific protein CCPI precursor; unnamed protein product
Gene Aliases: C11; CCP-1/C11; CCP-X; CCP1; CCPI; CGL-1; CGL-2; CGL1; CSP-B; CSP-C; CSPB; Ctla-1; CTLA1; CTSGL1; CTSGL2; GZB; HLP; RNKP-1; SECT
UniProt ID: (Human) P10144, (Human) P20718, (Rat) P18291, (Mouse) P04187
Entrez Gene ID: (Human) 3002, (Human) 2999, (Rat) 171528, (Mouse) 14939
T cell mediated cytotoxicity
proteolysis
negative regulation of translation
protein catabolic process
natural killer cell mediated cytotoxicity
defense response to bacterium
neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
granzyme-mediated programmed cell death signaling pathway
apoptotic process
positive regulation of establishment of protein localization to mitochondrion
plasma membrane repair
positive regulation of immune response to tumor cell
ceramide biosynthetic process
pyroptotic cell death
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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