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Invitrogen
HSD11B1 Polyclonal Antibody
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FIGURE: 1 / 3
HSD11B1 Antibody (PA5-115382) in IHC (P)
Immunohistochemistry analysis of HSD11B1 in mouse liver tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115382) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115382
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HSD11B1(Accession P28845), corresponding to amino acid residues M1-M50.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total HSD11B1.
Target Information
HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11-beta-HSD1; 11-beta-HSD1A/MCR; 11-beta-hydroxysteroid dehydrogenase, type 1; 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase; 11-DH; 11B-HSD1; 11beta-HSD-1; 11beta-HSD1; 11beta-HSD1A; 11beta-hydroxysteroid dehydrogenase type 1; 7-oxosteroid reductase; corticosteroid 11-beta-dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A); cortocosteroid 11-beta dehydrogenase; hydroxysteroid dehydrogenase, 11 beta type 1; liver-type 11-beta-HSD; MGC13539; OTTHUMP00000034650; short chain dehydrogenase/reductase family 26C member 1; unnamed protein product
Gene Aliases: 11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; LRRGT00065; SDR26C1
UniProt ID: (Human) P28845, (Mouse) P50172, (Rat) P16232
Entrez Gene ID: (Human) 3290, (Mouse) 15483, (Rat) 25116
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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