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Invitrogen

Menin Polyclonal Antibody

1 Published Figure
1 Reference
View all (23) Menin antibodies

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Menin Polyclonal Antibody

Product Details

PA5-115569

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MEN1(Accession O00255), corresponding to amino acid residues S183-M233.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900204

Product Specific Information

Antibody detects endogenous levels of total MEN1.

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: MEN1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; multiple endocrine neoplasia type I; similar to Homo sapiens MENIN; unnamed protein product

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Gene Aliases: MEAI; menin; SCG2

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UniProt ID: (Human) O00255, (Mouse) O88559, (Rat) Q9WVR8

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Entrez Gene ID: (Human) 4221, (Mouse) 17283, (Rat) 29417

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Function(s)
four-way junction DNA binding Y-form DNA binding transcription regulatory region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding DNA binding chromatin binding double-stranded DNA binding protein binding protein binding, bridging sequence-specific DNA binding phosphoprotein binding R-SMAD binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade ossification leukocyte homeostasis negative regulation of protein phosphorylation osteoblast fate commitment osteoblast development type B pancreatic cell differentiation chromatin remodeling regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus negative regulation of cell proliferation response to UV response to gamma radiation regulation of gene expression positive regulation of gene expression negative regulation of cell-substrate adhesion hemopoiesis positive regulation of transforming growth factor beta receptor signaling pathway regulation of activin receptor signaling pathway positive regulation of apoptotic process T-helper 2 cell differentiation positive regulation of cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle positive regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of organ growth embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation positive regulation of cell division palate development maternal process involved in female pregnancy regulation of type B pancreatic cell proliferation response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle DNA repair decidualization cellular response to glucose stimulus cellular response to peptide hormone stimulus
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