Search
Invitrogen
Menin Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115569
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MEN1(Accession O00255), corresponding to amino acid residues S183-M233.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MEN1.
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MEN1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; multiple endocrine neoplasia type I; similar to Homo sapiens MENIN; unnamed protein product
Gene Aliases: MEAI; menin; SCG2
UniProt ID: (Human) O00255, (Mouse) O88559, (Rat) Q9WVR8
Entrez Gene ID: (Human) 4221, (Mouse) 17283, (Rat) 29417
four-way junction DNA binding
Y-form DNA binding
transcription regulatory region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DNA binding
chromatin binding
double-stranded DNA binding
protein binding
protein binding, bridging
sequence-specific DNA binding
phosphoprotein binding
R-SMAD binding
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
ossification
leukocyte homeostasis
negative regulation of protein phosphorylation
osteoblast fate commitment
osteoblast development
type B pancreatic cell differentiation
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
negative regulation of cell proliferation
response to UV
response to gamma radiation
regulation of gene expression
positive regulation of gene expression
negative regulation of cell-substrate adhesion
hemopoiesis
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of activin receptor signaling pathway
positive regulation of apoptotic process
T-helper 2 cell differentiation
positive regulation of cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of organ growth
embryonic skeletal system morphogenesis
negative regulation of epithelial cell proliferation
positive regulation of cell division
palate development
maternal process involved in female pregnancy
regulation of type B pancreatic cell proliferation
response to transforming growth factor beta
negative regulation of cell cycle G1/S phase transition
regulation of G1/S transition of mitotic cell cycle
DNA repair
decidualization
cellular response to glucose stimulus
cellular response to peptide hormone stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support