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mGluR7 Polyclonal Antibody
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FIGURE: 1 / 2
mGluR7 Antibody (PA5-115575) in IHC (P)
Immunohistochemistry analysis of mGluR7 in human brain tissue sections. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115575) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115575
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRM7(Accession Q14831), corresponding to amino acid residues S874-I915.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total mGluR7.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40498; G protein-coupled receptor GRM7; G protein-coupled receptor, family C, group 1, member G; glutamate receptor; glutamate receptor, metabotropic 7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b; mGlu7a receptor; mGluR7; protein phosphatase 1, regulatory subunit 87; unnamed protein product
Gene Aliases: 6330570A01Rik; C030018L03; E130018M02Rik; GLUR7; Gpr1g; GPRC1G; MGLU7; MGLUR7; NEDSHBA; PPP1R87; SMN2; Tg(SMN2)89Ahmb
UniProt ID: (Human) Q14831, (Rat) P35400, (Mouse) Q68ED2
Entrez Gene ID: (Human) 2917, (Rat) 81672, (Mouse) 108073
group III metabotropic glutamate receptor activity
G-protein coupled receptor activity
voltage-gated calcium channel activity
calcium channel regulator activity
calcium ion binding
protein binding
glutamate receptor activity
adenylate cyclase inhibitor activity
glutamate binding
PDZ domain binding
protein dimerization activity
serine binding
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
calmodulin binding
identical protein binding
calcium-dependent protein binding
conditioned taste aversion
behavioral fear response
cell communication
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
sensory perception of sound
learning or memory
memory
short-term memory
associative learning
negative regulation of glutamate secretion
transmission of nerve impulse
signaling
adult behavior
multicellular organismal response to stress
negative regulation of neuron apoptotic process
neurological system process
regulation of synaptic transmission, glutamatergic
axon development
calcium ion transmembrane transport
presynaptic modulation of chemical synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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