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Invitrogen
PSEN2 Polyclonal Antibody
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FIGURE: 1 / 3
PSEN2 Antibody (PA5-115793) in ICC/IF
Immunocytochemistry analysis of PSEN2 in A549 cells (H2O2 treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with PSEN2 polyclonal antibody (Product # PA5-115793) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PSEN2(Accession P49810), corresponding to amino acid residues K306-E356.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Presenilin 2.
Target Information
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD3LP; AD5; Alzheimer disease 3-like; Alzheimer disease 4; E5-1; formerly known as STM2; homolog of the Alzheimer's disease gene; PS-2; PS-2short; PSEN 2; STM-2; unnamed protein product
Gene Aliases: AD3L; AD4; Ad4h; ALG-3; Alg3; CMD1V; PS-2; PS2; Psnl2; STM2
UniProt ID: (Human) P49810, (Rat) O88777, (Mouse) Q61144
Entrez Gene ID: (Human) 5664, (Rat) 81751, (Mouse) 19165
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
cell fate specification
somitogenesis
positive regulation of receptor recycling
negative regulation of protein phosphorylation
hair follicle development
hematopoietic progenitor cell differentiation
T cell activation involved in immune response
myeloid leukocyte differentiation
membrane protein ectodomain proteolysis
calcium ion transport
Notch signaling pathway
learning or memory
memory
protein transport
protein processing
dorsal/ventral neural tube patterning
embryonic limb morphogenesis
forebrain development
negative regulation of protein complex assembly
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
endoplasmic reticulum calcium ion homeostasis
beta-amyloid formation
Notch receptor processing, ligand-dependent
intracellular signal transduction
locomotion
negative regulation of epidermal growth factor receptor signaling pathway
amyloid precursor protein catabolic process
positive regulation of apoptotic process
skin morphogenesis
regulation of synaptic plasticity
lung alveolus development
thymus development
brain morphogenesis
beta-amyloid metabolic process
positive regulation of coagulation
T cell receptor signaling pathway
protein maturation
calcium ion homeostasis
cardiac muscle contraction
neuron cellular homeostasis
regulation of postsynapse organization
regulation of calcium import into the mitochondrion
protein catabolic process at postsynapse
neuroinflammatory response
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic signaling pathway
Notch receptor processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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