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Invitrogen
AMPK alpha-2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115794
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRKAA2(Accession P54646), corresponding to amino acid residues L363-Y413.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PRKAA2.
Target Information
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-AMP-activated protein kinase, catalytic alpha-2 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMPK alpha 2; AMPK alpha-2 variant 2; AMPK alpha-2 variant 3; AMPK subunit alpha-2; AMPK-alpha-2 chain; EC 2.7.11.1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase; protein kinase, AMP-activated, alpha 2 catalytic subunit; unnamed protein product
Gene Aliases: AMPK; AMPK2; AMPKa2; PRKAA
UniProt ID: (Human) P54646
Entrez Gene ID: (Human) 5563
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
AMP-activated protein kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
protein serine kinase activity
histone H2BS36 kinase activity
chromatin remodeling
signal transduction
lipid biosynthetic process
positive regulation of autophagy
negative regulation of gene expression
positive regulation of macroautophagy
regulation of macroautophagy
regulation of lipid metabolic process
cellular response to nutrient levels
negative regulation of TOR signaling
adiponectin-activated signaling pathway
cellular response to oxidative stress
cellular response to glucose starvation
glucose homeostasis
regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of glycolytic process
fatty acid homeostasis
regulation of stress granule assembly
regulation of microtubule cytoskeleton organization
cellular response to calcium ion
cellular response to glucose stimulus
energy homeostasis
positive regulation of cellular protein localization
negative regulation of hepatocyte apoptotic process
negative regulation of TORC1 signaling
lipid droplet disassembly
protein localization to lipid particle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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