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Invitrogen
SLC7A5 Polyclonal Antibody
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FIGURE: 1 / 7
SLC7A5 Antibody (PA5-115916) in ICC/IF
Immunocytochemistry analysis of SLC7A5 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115916) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115916
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC7A5(Accession Q01650), corresponding to amino acid residues F399-V449.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC7A5.
Target Information
Solute carrier family 7 member 5 also known as large neutral amino acids transporter small subunit 1 is a protein that in humans is encoded by the SLC7A5 gene.It is sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc.It involved in cellular amino acid uptake and the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.Acts as an amino acid exchanger and plays a role in neuronal cell proliferation (neurogenesis) in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 4F2; 4F2 LC; 4F2 light chain; 4F2HC; 4T2HC; CD98 light chain; CD98HC; E16; integral membrane protein E16; L-type amino acid transporter 1; LAT1; MDU1; MP hLAT1; NACAE; sodium-independent neutral amino acid transporter LAT1; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; solute carrier family 7 member 5; unnamed protein product
Gene Aliases: 4F2LC; CD98; D0H16S474E; D16S469E; E16; Gm42049; LAT1; MPE16; TA1
UniProt ID: (Human) Q01650, (Mouse) Q9Z127
Entrez Gene ID: (Human) 8140, (Mouse) 20539
protein binding
amino acid transmembrane transporter activity
aromatic amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
L-amino acid transmembrane transporter activity
L-leucine transmembrane transporter activity
L-tryptophan transmembrane transporter activity
antiporter activity
thyroid hormone transmembrane transporter activity
transmembrane transporter activity
peptide antigen binding
positive regulation of cytokine production involved in immune response
amino acid transmembrane transport
amino acid transport
negative regulation of autophagy
negative regulation of gene expression
response to muscle activity
neutral amino acid transport
L-amino acid transport
isoleucine transport
leucine transport
methionine transport
phenylalanine transport
proline transport
tryptophan transport
tyrosine transport
valine transport
alanine transport
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of interleukin-4 production
cellular response to glucose starvation
xenobiotic transport
transmembrane transport
response to hyperoxia
positive regulation of glial cell proliferation
thyroid hormone transport
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
amino acid import across plasma membrane
liver regeneration
transport across blood-brain barrier
L-histidine transport
L-alpha-amino acid transmembrane transport
cellular response to L-arginine
L-leucine import across plasma membrane
L-tryptophan transmembrane transport
negative regulation of vascular associated smooth muscle cell apoptotic process
positive regulation of leucine import across plasma membrane
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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