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Invitrogen
SMARCA1 Polyclonal Antibody
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FIGURE: 1 / 9
SMARCA1 Antibody (PA5-115927) in ICC/IF
Immunocytochemistry analysis of SMARCA1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115927) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SMARCA1(Accession P28370), corresponding to amino acid residues E850-A900.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SMARCA1.
Target Information
Members of this G protein family are characterized by the presence of conserved SNF2 domain, a helicase-like region. They also have an ATPase activity and are thought to have a significant role regulating chromatin remodeling. Although SNF2L1 has a ubiquitous expression pattern, its active form is expressed in neurons suggesting a possible role in promoting neurite outgrowth and regulating neuronal physiology. Principal Names: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 1 (SMARCA1); SNF2L1; SNF2LB; Possible global transcription activator SNF2L1; SWI2 Official Gene Symbol: SMARCA1 Gen Bank Accession Number: NP_620604 Gene ID: 6594 (Human) Gene Map Locus: Xq25 (Human) SNF2L1, a ~123KDa protein, is a member of SWI/SNF family of proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA1; DKFZp686D1623; DNA-dependent ATPase SNF2L; FLJ41547; global transcription activator homologous sequence; global transcription activator SNF2L1; nucleosome-remodeling factor subunit SNF2L; probable global transcription activator SNF2L1; RP3-353H6.2; SNF2-like 1; sucrose nonfermenting 2-like protein 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1; truncated isoform of SNF2L; unnamed protein product
Gene Aliases: 5730494M04Rik; hSNF2L; ISWI; NURF140; RGD1561046; SNF2L; SNF2L1; SNF2LB; SNF2LT; SWI; SWI2
UniProt ID: (Human) P28370, (Mouse) Q6PGB8
Entrez Gene ID: (Human) 6594, (Mouse) 93761, (Rat) 317575
DNA binding
chromatin binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
ATPase activity
nucleosome binding
annealing helicase activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
ATP-dependent chromatin remodeler activity
nucleosome array spacer activity
chromatin remodeling
regulation of transcription, DNA-templated
brain development
neuron differentiation
heterochromatin assembly
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neural tube closure
regulation of neural precursor cell proliferation
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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