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Invitrogen
SOX11 Polyclonal Antibody
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FIGURE: 1 / 2
SOX11 Antibody (PA5-115950) in ICC/IF
Immunocytochemistry analysis of SOX11 in 3T3 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115950) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115950
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SOX11(Accession P35716), corresponding to amino acid residues E378-D428.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SOX11.
Target Information
This intronless gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: putative transcription factor; SOX-11; SRY; SRY (sex determining region Y)-box 11; SRY (sex-determining region Y)-box 11; SRY box 11; SRY-box 11; SRY-box containing gene 11; SRY-related HMG-box gene 11; unnamed protein product
Gene Aliases: 1110038H03Rik; 6230403H02Rik; CSS9; end1; IDDMOH; MRD27
UniProt ID: (Human) P35716, (Mouse) Q7M6Y2, (Rat) P0C1G9
Entrez Gene ID: (Human) 6664, (Mouse) 20666, (Rat) 84046
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific double-stranded DNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
kidney development
lens morphogenesis in camera-type eye
outflow tract morphogenesis
noradrenergic neuron differentiation
nervous system development
central nervous system development
brain development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell development
oligodendrocyte development
glial cell proliferation
regulation of transforming growth factor beta receptor signaling pathway
spinal cord development
glial cell development
neuron differentiation
positive regulation of BMP signaling pathway
positive regulation of hippo signaling
skeletal muscle cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
sympathetic nervous system development
embryonic digestive tract morphogenesis
camera-type eye morphogenesis
embryonic skeletal system morphogenesis
negative regulation of lymphocyte proliferation
positive regulation of neurogenesis
hard palate development
soft palate development
negative regulation of glial cell proliferation
ventricular septum morphogenesis
lung morphogenesis
neuroepithelial cell differentiation
eyelid development in camera-type eye
cornea development in camera-type eye
closure of optic fissure
positive regulation of stem cell proliferation
negative regulation of transcription regulatory region DNA binding
positive regulation of lens epithelial cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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