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Invitrogen

CHRNA7 Polyclonal Antibody

View all (15) CHRNA7 antibodies

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CHRNA7 Polyclonal Antibody

Product Details

PA5-116644

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2901275

Product Specific Information

Positive Samples: Mouse brain, Mouse heart, Rat brain

Immunogen sequence: ASPPSTPPWD PGHIPGASVR PAPGPVSLQG EFQRKLYKEL VKNYNPLERP VANDSQPLTV YFSLSLLQIM DVDEKNQVLT TNIWLQMSWT DHYLQWNVSE YPGVKTVRFP DGQIWKPDIL LYNSADERFD ATFHTNVLVN SSGHCQYLPP GIFKSSCYID VRWFPFDVQH CKLKFGSWSY GGWSLDLQMQ EADISGYIPN GEWDLVGI

Target Information

Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a7 nicotinic acetylcholine receptor; acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha 7 neuronal nicotinic acetylcholine receptor; alpha 7-2; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; cytotransmitter gated ion channel; D-10; nAChR alpha7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal nicotinic acetycholine receptor alpha 7; neurotransmitter receptor; acra7; nicotinic acetylcholine receptor subunit alpha-7; nicotinic receptor alpha 7 subunit; unnamed protein product

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Gene Aliases: a7nAChR; Acra7; alpha7; BTX; CHRNA7-2; nAchR; nAChR7; NACHRA7; NARAD

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UniProt ID: (Human) P36544, (Mouse) P49582, (Rat) Q05941

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Entrez Gene ID: (Human) 1139, (Mouse) 11441, (Rat) 25302

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Function(s)
beta-amyloid binding transmembrane signaling receptor activity ion channel activity extracellular ligand-gated ion channel activity calcium channel activity protein binding acetylcholine receptor activity toxic substance binding chloride channel regulator activity acetylcholine-gated cation channel activity neurotransmitter receptor activity acetylcholine binding protein homodimerization activity adenylate cyclase binding protein kinase binding ATPase binding scaffold protein binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Process(es)
response to hypoxia positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure ion transport cation transport calcium ion transport cellular calcium ion homeostasis endocytosis signal transduction chemical synaptic transmission synaptic transmission, cholinergic learning or memory memory positive regulation of cell proliferation associative learning response to cold positive regulation of gene expression regulation of norepinephrine secretion neuronal action potential sperm motility response to food regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production ion transmembrane transport response to nicotine behavioral response to nicotine T cell activation B cell activation regulation of membrane potential ovulation cycle negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade response to ethanol positive regulation of angiogenesis behavioral response to ethanol regulation of inflammatory response negative regulation of inflammatory response modulation of synaptic transmission synapse organization cognition sensory processing positive regulation of protein metabolic process regulation of synapse structural plasticity membrane depolarization excitatory postsynaptic potential synaptic transmission involved in micturition generation of ovulation cycle rhythm negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade acetylcholine receptor signaling pathway dendritic spine organization modulation of excitatory postsynaptic potential presynaptic modulation of chemical synaptic transmission dendrite arborization negative regulation of cytokine production involved in inflammatory response positive regulation of long-term synaptic potentiation positive regulation of beta-amyloid formation negative regulation of beta-amyloid formation negative regulation of intracellular signal transduction regulation of amyloid precursor protein catabolic process response to amyloid-beta response to acetylcholine regulation of amyloid fibril formation activation of protein kinase C activity ligand-gated ion channel signaling pathway positive regulation of excitatory postsynaptic potential regulation of response to drug cell communication short-term memory signaling calcium ion transmembrane transport regulation of nitric oxide metabolic process response to carbamate
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