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Invitrogen
KChIP3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-11665
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KChIP3
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.6 mg/mL
Amount
640 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis. KChIP3 has activities beyond the modulation of Kv4 currents. It has been shown that KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos. Thus, KCHiP3 is the first known calcium-binding protein to function as a DNA-binding transcriptional regulator. KChIP3 is also found associated with the presenilins and is implicated in the mediation of beta-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 3; calcium binding protein; calcium-binding protein; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin, presenilin-binding protein, EF hand transcription factor; calsenilin/KChIP3 T+; calsenilin/KChIP3 T-; downstream regulatory element antagonist T+; downstream regulatory element antagonist T-; DRE-antagonist modulator; KCNIP3-Ia; KCNIP3-Ib#II; Kv channel interacting protein 3, calsenilin; kv channel-interacting protein 3; neuronal calcium sensor-1 homolog; potassium channel interacting protein 3; recoverin-family member; unnamed protein product
Gene Aliases: 4933407H12Rik; CSEN; DREAM; KCHIP3
UniProt ID: (Human) Q9Y2W7, (Mouse) Q9QXT8
Entrez Gene ID: (Human) 30818, (Mouse) 56461
magnesium ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
calcium ion binding
protein binding
potassium channel regulator activity
calcium-dependent protein binding
protein homodimerization activity
sequence-specific DNA binding
ion channel binding
negative regulation of transcription from RNA polymerase II promoter
signal transduction
regulation of signal transduction
response to magnesium ion
protein localization to plasma membrane
regulation of potassium ion transmembrane transport
potassium ion transport
intracellular protein transport
sensory perception of pain
regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
response to pain
behavioral response to pain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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