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Invitrogen
HMGCR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-116675
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.85 mg/mL
Amount
185 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse spleen, Rat brain
Immunogen sequence: ASGPTNEDL
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl coenzyme A reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269; unnamed protein product
Gene Aliases: 3H3M; HMG-CoAR; LDLCQ3; LGMDR28; MYPLG; Red
UniProt ID: (Human) P04035, (Rat) P51639, (Mouse) Q01237
Entrez Gene ID: (Human) 3156, (Rat) 25675, (Mouse) 15357
cholesterol biosynthetic process
ubiquinone metabolic process
response to nutrient
positive regulation of cell proliferation
isoprenoid biosynthetic process
visual learning
farnesyl diphosphate biosynthetic process, mevalonate pathway
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
sterol biosynthetic process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
response to nutrient levels
positive regulation of stress-activated MAPK cascade
geranylgeranyl diphosphate biosynthetic process
zymosterol biosynthetic process
negative regulation of protein catabolic process
cholesterol homeostasis
negative regulation of apoptotic process
negative regulation of MAP kinase activity
myoblast differentiation
response to ethanol
positive regulation of vasoconstriction
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
negative regulation of protein secretion
long-term synaptic potentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
triglyceride homeostasis
regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
response to cholesterol
negative regulation of beta-amyloid clearance
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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