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Phospho-Claudin 4 (Tyr208) Polyclonal Antibody
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Phospho-Claudin 4 (Tyr208) Antibody (PA5-118685) in IHC (P)
Immunohistochemical analysis of Phospho-Claudin 4 (Tyr208) in Human kidney tissue using a Phospho-Claudin 4 (Tyr208) polyclonal antibody (Product # PA5-118685). The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-118685
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CLDN4(Accession O14493), corresponding to amino acid residues around phosphorylated Tyr208.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Claudin 4 only when phosphorylated at Tyr208.
Target Information
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CLAUDIN4; clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPE-R; CPE-receptor; h CPE-receptor; unnamed protein product; Williams-Beuren syndrome chromosomal region 8 protein
Gene Aliases: Cep-r; CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8
UniProt ID: (Human) O14493, (Mouse) O35054
Entrez Gene ID: (Human) 1364, (Rat) 304407, (Mouse) 12740
female pregnancy
circadian rhythm
regulation of cell morphogenesis
positive regulation of cell migration
response to progesterone
establishment of skin barrier
renal absorption
positive regulation of wound healing
paracellular transport
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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