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Invitrogen
GPX4 Polyclonal Antibody
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FIGURE: 1 / 13
GPX4 Antibody (PA5-119142) in IHC (P)
Immunohistochemistry (Paraffin) analysis of GPX4 in mouse stomach tissue using GPX4 Polyclonal Antibody (Product # PA5-119142) (10 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-119142
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Glutathione Peroxidase 4. The antigen corresponds to amino acid range 74-197 of the target protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; HGNC:4556; phospholipid hydroperoxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; selenoprotein GPX4; selenoprotein PHGPx or GPx4; sperm nuclei glutathione peroxidase; sperm nucleus glutathione peroxidase; unnamed protein product
Gene Aliases: GPx-4; GSHPx-4; MCSP; mtPHGPx; PHGPx; SMDS; snGPx; snPHGPx
UniProt ID: (Human) P36969, (Mouse) O70325
Entrez Gene ID: (Human) 2879, (Mouse) 625249
phospholipid metabolic process
response to oxidative stress
spermatogenesis
arachidonic acid metabolic process
lipoxygenase pathway
response to estradiol
cellular response to oxidative stress
long-chain fatty acid biosynthetic process
protein polymerization
cellular oxidant detoxification
negative regulation of ferroptosis
chromatin organization
apoptotic process
dendrite development
cerebellum development
response to lipopolysaccharide
multicellular organism growth
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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