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Perlecan Polyclonal Antibody
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FIGURE: 1 / 13
Perlecan Antibody (PA5-119185) in ICC/IF
Immunocytochemistry analysis of Perlecan in Human U2OS cells using Perlecan Polyclonal Antibody (Product # PA5-119185) at a dilution of 30 µg/mL, followed by secondary antibody staining with 2 µg/mL FITC-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-119185
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Heparan Sulfate Proteoglycan 2. The antigen corresponds to amino acid range 4149-4391 of the target protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: basement membrane proteoglycan; endorepellin (domain V region); Hspg2; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; proteoglycan; putative proteoglycan; matrix protein; RP11-132G19.2; unnamed protein product
Gene Aliases: AABR07073181.1; HSPG; Pcn; Per; PLC; PRCAN; SJA; SJS; SJS1
UniProt ID: (Human) P98160, (Mouse) Q05793
Entrez Gene ID: (Pig) 100517288, (Human) 3339, (Rat) 313641, (Mouse) 15530
beta-amyloid binding
integrin binding
calcium ion binding
protein binding
extracellular matrix structural constituent conferring compression resistance
low-density lipoprotein particle receptor binding
binding, bridging
protease binding
dystroglycan binding
axon guidance receptor activity
collagen V binding
response to hypoxia
positive regulation of endothelial cell proliferation
endochondral ossification
chondrocyte differentiation
receptor-mediated endocytosis
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell adhesion
smoothened signaling pathway
axon guidance
brain development
embryo implantation
protein localization
negative regulation of cell proliferation
response to xenobiotic stimulus
cell differentiation
extracellular matrix organization
organ regeneration
regulation of synaptic transmission, cholinergic
negative regulation of synaptic transmission, cholinergic
protein localization to synapse
negative regulation of neuron apoptotic process
embryonic skeletal system morphogenesis
cardiac muscle tissue development
synapse organization
cartilage development involved in endochondral bone morphogenesis
circulatory system development
negative regulation of amyloid fibril formation
organ morphogenesis
tissue development
lipid metabolic process
inflammatory response
negative regulation of angiogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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