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Myostatin Polyclonal Antibody
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FIGURE: 1 / 8
Myostatin Antibody (PA5-11936) in IHC (P)
Immunohistochemistry analysis of Myostatin in formalin-fixed and paraffin-embedded human skeletal muscle tissue. Samples were incubated with Myostatin polyclonal antibody (Product # PA5-11936) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-11936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human Myostatin (GDF8)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, porcine and non-human primate based on sequence homology.
Target Information
The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: compact; GDF-8; growth differentiation factor 8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin; myostatin-b; transforming growth factor-beta superfamily member; unnamed protein product
Gene Aliases: Cmpt; GDF8; MSLHP; MSTN
UniProt ID: (Human) O14793, (Mouse) O08689
Entrez Gene ID: (Human) 2660, (Mouse) 17700
transforming growth factor beta receptor signaling pathway
muscle organ development
skeletal muscle tissue development
response to gravity
positive regulation of lamellipodium assembly
positive regulation of macrophage chemotaxis
skeletal muscle atrophy
negative regulation of muscle hypertrophy
skeletal muscle satellite cell differentiation
myoblast migration involved in skeletal muscle regeneration
response to muscle activity
ovulation cycle process
response to testosterone
skeletal muscle tissue regeneration
response to estrogen
response to ethanol
negative regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
muscle cell cellular homeostasis
negative regulation of skeletal muscle tissue growth
response to glucocorticoid
response to electrical stimulus
negative regulation of protein kinase B signaling
trophoblast cell migration
cellular response to hypoxia
cellular response to dexamethasone stimulus
negative regulation of skeletal muscle satellite cell proliferation
negative regulation of satellite cell differentiation
negative regulation of myoblast proliferation
positive regulation of defense response to virus by host
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
mitophagy in response to mitochondrial depolarization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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