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Invitrogen
PSAP Polyclonal Antibody
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FIGURE: 1 / 12
PSAP Antibody (PA5-119361) in ICC/IF
Immunocytochemistry analysis of PSAP in Human HepG2 cells using PSAP Polyclonal Antibody (Product # PA5-119361) at a dilution of 20 µg/mL, followed by secondary antibody staining with 2 µg/mL FITC-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-119361
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Prosaposin. The antigen corresponds to amino acid range 17-524 of the target protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: co-beta glucosidase precursor; precursor of saposins; proactivator polypeptide; prosaposin; prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); PSAP; saposin-A; saposin-B; Saposin-B-Val; saposin-C; saposin-D; sphingolipid activator protein-1; sphingolipid activator protein-2; sulfated glycoprotein 1; sulfated glycoprotein precursor; unnamed protein product
Gene Aliases: GLBA; PARK24; PSAPD; SAP1; SAP2; SGP-1; SGP1A
UniProt ID: (Human) P07602, (Rat) P10960
Entrez Gene ID: (Human) 5660, (Pig) 100153167, (Rat) 25524
protease binding
protein binding
phospholipid binding
lipid binding
sphingolipid activator protein activity
identical protein binding
protein homodimerization activity
scaffold protein binding
ganglioside GM1 binding
ganglioside GM2 binding
ganglioside GM3 binding
ganglioside GT1b binding
ganglioside GP1c binding
lipid chaperone activity
G-protein coupled receptor binding
lipid antigen binding
scaffold/adaptor protein
lipid metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process
lysosomal transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
gene expression
regulation of autophagy
regulation of lipid metabolic process
sphingolipid catabolic process
prostate gland growth
epithelial cell differentiation involved in prostate gland development
ganglioside GM1 transport to membrane
NK T cell differentiation
corneocyte development
glycolipid metabolic process
ceramide metabolic process
glucosylceramide metabolic process
galactosylceramide catabolic process
intracellular protein transport
sensory perception of sound
protein secretion
antigen processing and presentation
cerebellar Purkinje cell differentiation
cellular response to reactive oxygen species
myelination
regulation of MAPK cascade
positive regulation of MAPK cascade
glycolipid transport
developmental growth
neurological system process
neuromuscular process controlling balance
positive regulation of hydrolase activity
micturition
inclusion body assembly
cochlea development
walking behavior
cornified envelope assembly
lysosomal protein catabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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