Search
Invitrogen
PP1 alpha Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
PP1 alpha Antibody (PA5-119781) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat large intestine tissue using PP1 alpha Polyclonal Antibody (Product # PA5-119781). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the PP1 alpha antibody a... View More
Product Details
PA5-119781
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human PPP1CA aa 291-330.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: MCF-7 cell lysate, A549 cell lysate, K562 cell lysate, Hela cell lysate, rat brain tissue lysate, mouse brain tissue lysate, rat large intestine tissue, mouse kidney tissue.
Subcellular Location: Nucleus, nucleoplasm, nucleolus, cytoplasm.
Target Information
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: GADD34; MGC15877; MGC1674; PP-1A; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase I alpha subunit (PPPIA) (EC 3.1.3.16); Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1d; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; testicular tissue protein Li 155; unnamed protein product
Gene Aliases: dism2; PP-1A; PP1A; PP1alpha; PPP1A; Ppp1c; PPP1CA
UniProt ID: (Human) P62136, (Mouse) P62137, (Rat) P62138
Entrez Gene ID: (Human) 5499, (Mouse) 19045, (Rat) 24668
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
iron ion binding
protein binding
protein phosphatase 1 binding
hydrolase activity
phosphatase activity
ribonucleoprotein complex binding
macromolecular complex binding
metal ion binding
transition metal ion binding
cadherin binding involved in cell-cell adhesion
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
protein complex binding
protein phosphatase
telomere maintenance
promoter clearance from RNA polymerase II promoter
glycogen metabolic process
regulation of glycogen biosynthetic process
regulation of glycogen catabolic process
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein dephosphorylation
response to lead ion
dephosphorylation
lung development
circadian regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
telomere maintenance in response to DNA damage
regulation of translational initiation in response to stress
positive regulation of glycogen biosynthetic process
branching morphogenesis of an epithelial tube
protein stabilization
cell division
regulation of canonical Wnt signaling pathway
double-strand break repair via alternative nonhomologous end joining
cell-cell adhesion
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
carbohydrate metabolic process
regulation of translation
cell cycle
female meiotic division
cellular process
rhythmic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support