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Invitrogen
PPP1R9A Polyclonal Antibody
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FIGURE: 1 / 6
PPP1R9A Antibody (PA5-119842) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of Neurabin 1 in SH-SY5Y cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 10% negative goat serum for 15 minutes at room temperature. Cells were probed with PPP1R9A Polyclonal Antibody (Product # PA5-119842) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 conjugate-Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stai... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-119842
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human Neurabin 1 aa 1-200.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Rat brain tissue, SH-SY5Y, human liver carcinoma tissue, mouse brain tissue.
Subcellular Location: Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome.
Target Information
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-binding protein neurabin; neurabin-I; neural tissue-specific F-actin binding protein; neural tissue-specific F-actin-binding protein I; protein phosphatase 1, regulatory (inhibitor) subunit 9A; protein phosphatase I regulatory subunit 9A; unnamed protein product
Gene Aliases: 2810430P21Rik; 4930518N04Rik; 5330407E15; A230094E16Rik; Neb1; Neurabin-I; NRB; NRB1; NRBI; p180; PP1bp175
UniProt ID: (Human) Q9ULJ8, (Rat) O35867
Entrez Gene ID: (Human) 55607, (Mouse) 243725, (Rat) 84685
actin filament organization
calcium-mediated signaling
neuron projection development
positive regulation of neuron projection development
actin cytoskeleton organization
regulation of actin filament polymerization
positive regulation of protein kinase activity
modulation of synaptic transmission
regulation of filopodium assembly
negative regulation of stress fiber assembly
regulation of synapse structural plasticity
regulation of synapse assembly
excitatory postsynaptic potential
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
cellular response to toxic substance
postsynaptic actin cytoskeleton organization
negative regulation of long-term synaptic potentiation
positive regulation of long term synaptic depression
negative regulation of spontaneous neurotransmitter secretion
neuron development
synapse organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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