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Invitrogen

PI3K p85 alpha Polyclonal Antibody

View all (33) PI3K p85 alpha antibodies

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PI3K p85 alpha Polyclonal Antibody

Product Details

PA5-119989

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:200
-

Flow Cytometry (Flow)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within C-terminal human PI3-kinase p85 subunit alpha.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 40% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913561

Product Specific Information

Positive Control: Jurkat, PC12, NIH/3T3

Subcellular Location: Cytoplasm, nucleus

Target Information

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: growth factor receptor bound 1; p55-GAMMA; p55PIK; p85-alpha; GRB1; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3 kinase-associated p85; PI3-kinase p85 subunit alpha; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; PI3K-p46; polypeptide 1 p85 alpha; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-alpha; RP4-533D7.2; unnamed protein product

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Gene Aliases: AGM7; GRB1; IMD36; p50alpha; p55alpha; p85; p85-ALPHA; p85alpha; PI3K; PI3KA; PIK3R1

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UniProt ID: (Human) P27986, (Mouse) P26450, (Rat) Q63787

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Entrez Gene ID: (Human) 5295, (Mouse) 18708, (Rat) 25513

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Function(s)
phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity GTPase activator activity insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding kinase regulator activity kinase activator activity protein phosphatase binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding ErbB-3 class receptor binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity phosphatidylinositol kinase activity enzyme-substrate adaptor activity phosphatidylinositol 3-kinase activator activity receptor binding platelet-derived growth factor receptor binding calmodulin binding protein C-terminus binding transcription factor binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein domain specific binding estrogen receptor binding receptor tyrosine kinase binding ubiquitin protein ligase binding ATPase binding phosphoprotein binding kinase modulator
Process(es)
cellular glucose homeostasis negative regulation of cell-matrix adhesion positive regulation of leukocyte migration transcription from RNA polymerase II promoter protein import into nucleus immune response negative regulation of cell adhesion signal transduction insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of lamellipodium assembly protein transport cytokine-mediated signaling pathway B cell differentiation T cell differentiation osteoclast differentiation positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of RNA splicing regulation of toll-like receptor 4 signaling pathway substrate adhesion-dependent cell spreading cellular response to UV response to endoplasmic reticulum stress interleukin-18-mediated signaling pathway natural killer cell mediated cytotoxicity positive regulation of protein import into nucleus negative regulation of apoptotic process protein kinase B signaling negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation protein stabilization positive regulation of filopodium assembly regulation of stress fiber assembly negative regulation of stress fiber assembly growth hormone receptor signaling pathway T follicular helper cell differentiation myeloid leukocyte migration positive regulation of focal adhesion disassembly positive regulation of endoplasmic reticulum unfolded protein response regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane positive regulation of protein phosphorylation glucose metabolic process protein phosphorylation transport negative regulation of heart rate positive regulation of gene expression negative regulation of muscle cell apoptotic process phosphatidylinositol 3-kinase signaling negative regulation of cell-cell adhesion positive regulation of cell migration response to insulin phosphatidylinositol-3-phosphate biosynthetic process positive regulation of transcription factor import into nucleus regulation of phosphatidylinositol 3-kinase activity positive regulation of myoblast differentiation negative regulation of blood pressure negative regulation of proteolysis negative regulation of smooth muscle cell proliferation response to glucocorticoid NFAT protein import into nucleus response to cAMP regulation of establishment of protein localization to plasma membrane response to yeast aging response to nutrient response to fructose response to iron(II) ion response to estradiol response to progesterone response to testosterone response to drug response to amino acid response to ethanol response to fatty acid response to growth factor cellular response to fatty acid response to dexamethasone
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