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          • Primary Antibodies ›
          • MEF2C Antibodies

          Invitrogen

          MEF2C Polyclonal Antibody

          View all (68) MEF2C antibodies

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          Cite MEF2C Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (4)
          MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          MEF2C Antibody (PA5-120156) in IHC (P)

          Immunohistochemistry analysis of MEF2C in paraffin-embedded human endometrium cancer. Samples were incubated with MEF2C Polyclonal antibody (Product # PA5-120156) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2C Antibody in Western Blot (WB)
          MEF2C Polyclonal Antibody

          Product Details

          PA5-120156

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:100
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:100
          -

          ELISA (ELISA)

          1 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant fusion protein containing a sequence corresponding to amino acids 170-380 of human MEF2C (NP_0023882)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          3.97 mg/mL

          Amount

          397 µg

          Purification

          Affinity Chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2913728

          Product Specific Information

          Positive test controls include: Mouse brain. The target is usually found in the following locations: Nucleus.

          Immunogen sequence: LPLAHPSLQR NSMSPGVTHR PPSAGNTGGL MGGDLTSGAG TSAGNGYGNP RNSPGLLVSP GNLNKNMQAK SPPPMNLGMN NRKPDLRVLI PPGSKNTMPS VSEDVDLLLN QRINNSQSAQ SLATPVVSVA TPTLPGQGMG GYPSAISTTY GTEYSLSSAD LSSLSGFNTA SALHLGSVTG WQQQHLHNMP PSALSQLGAC TSTHLSQSSN L

          Target Information

          MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: MADS box transcription enhancer factor 2, polypeptide C; Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; unnamed protein product

          View more View less

          Gene Aliases: 5430401D19Rik; 9930028G15Rik; AV011172; C5DELq14.3; DEL5q14.3; Mef2; MEF2C; NEDHSIL

          View more View less

          UniProt ID: (Human) Q06413, (Mouse) Q8CFN5

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          Entrez Gene ID: (Human) 4208, (Mouse) 17260

          View more View less

          Function(s)
          transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding AT DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone deacetylase binding protein heterodimerization activity protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding activating transcription factor binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding HMG box domain binding MADS box transcription factor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade blood vessel development osteoblast differentiation neuron migration B cell homeostasis heart looping endochondral ossification blood vessel remodeling chondrocyte differentiation germinal center formation regulation of germinal center formation response to ischemia primary heart field specification secondary heart field specification outflow tract morphogenesis sinoatrial valve morphogenesis cardiac ventricle formation regulation of transcription, DNA-templated apoptotic process humoral immune response nervous system development heart development muscle organ development skeletal muscle tissue development muscle cell fate determination learning or memory positive regulation of gene expression negative regulation of gene expression neural crest cell differentiation myotube differentiation cell differentiation neuron differentiation platelet formation negative regulation of ossification melanocyte differentiation positive regulation of bone mineralization positive regulation of B cell proliferation cellular response to trichostatin A B cell proliferation positive regulation of MAPK cascade regulation of neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration regulation of megakaryocyte differentiation positive regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neurotransmitter secretion regulation of synaptic plasticity positive regulation of skeletal muscle tissue development neuron development cell morphogenesis involved in neuron differentiation B cell receptor signaling pathway smooth muscle cell differentiation regulation of synapse assembly regulation of synaptic transmission, glutamatergic ventricular cardiac muscle cell differentiation regulation of synaptic activity positive regulation of cardiac muscle cell proliferation excitatory postsynaptic potential regulation of dendritic spine development renal tubule morphogenesis cellular response to lipopolysaccharide cellular response to calcium ion cellular response to parathyroid hormone stimulus cellular response to xenobiotic stimulus cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus glomerulus morphogenesis nephron tubule epithelial cell differentiation NMDA selective glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of vascular endothelial cell proliferation positive regulation of macrophage apoptotic process positive regulation of cardiac muscle cell differentiation positive regulation of behavioral fear response epithelial cell proliferation involved in renal tubule morphogenesis positive regulation of skeletal muscle cell differentiation transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development positive regulation of cardiac muscle hypertrophy positive regulation of alkaline phosphatase activity cardiac muscle hypertrophy in response to stress monocyte differentiation cellular response to drug skeletal muscle cell differentiation positive regulation of MAP kinase activity cell fate commitment embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation cardiac muscle cell differentiation palate development transdifferentiation regulation of sarcomere organization cartilage morphogenesis cellular response to retinoic acid cellular response to growth factor stimulus positive regulation of cell proliferation in bone marrow positive regulation of protein homodimerization activity regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
          It has to be done as per old AB suggested Products section.

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