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Invitrogen
FSHR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-120299
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 631-695 of human FSHR (NP_000136.2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.78 mg/mL
Amount
178 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: SKOV3, Mouse testis, Rat ovary. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Immunogen sequence: KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS TVHNTHPRNG HCSSAPRVTS GSTYILVPLS HLAQN
Target Information
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: follitropin receptor; FSH receptor; FSH-R; G-protein coupled receptor; FSHR; unnamed protein product
Gene Aliases: FSHR1; FSHRO; LGR1; ODG1
UniProt ID: (Human) P23945, (Rat) P20395, (Mouse) P35378
Entrez Gene ID: (Human) 2492, (Rat) 25449, (Mouse) 14309
ovarian follicle development
primary ovarian follicle growth
regulation of protein phosphorylation
regulation of systemic arterial blood pressure
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
spermatogenesis
spermatid development
locomotory behavior
male gonad development
hormone-mediated signaling pathway
cellular water homeostasis
regulation of platelet-derived growth factor receptor signaling pathway
ovulation cycle process
neuron projection development
regulation of hormone metabolic process
regulation of chromosome organization
regulation of intracellular estrogen receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
sperm chromatin condensation
insulin secretion involved in cellular response to glucose stimulus
follicle-stimulating hormone signaling pathway
regulation of MAPK cascade
transcytosis
regulation of osteoclast differentiation
negative regulation of bone resorption
positive regulation of protein kinase B signaling
Sertoli cell development
Sertoli cell proliferation
uterus development
regulation of acetylcholine metabolic process
positive regulation of ERK1 and ERK2 cascade
cellular response to follicle-stimulating hormone stimulus
basement membrane organization
MAPK cascade
female gamete generation
gonad development
female gonad development
response to hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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