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Invitrogen
KSR1 Polyclonal Antibody
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Product Details
PA5-120331
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 320-420 of human KSR1 (NP_055053.1).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.69 mg/mL
Amount
169 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: U-251MG, HeLa, Jurkat, mouse brain, mouse spleen, mouse testis, mouse kidney, mouse lung, rat brain. The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum membrane, Membrane, Peripheral membrane protein.
Immunogen sequence: SSPAPFPTSS NPSSATTPPN PSPGQRDSRF NFPAAYFIHH RQQFIFPVPS AGHCWKCLLI AESLKENAFN ISAFAHAAPL PEAADGTRLD DQPKADVLEA H
Target Information
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP kinase; HB protein; kinase KSR1; Kinase suppressor of Ras 1; mKSR1; OTTHUMP00000162931; Protein Hb; protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author.; unnamed protein product
Gene Aliases: AW492498; B-KSR1; D11Bhm183e; D11Bhm184e; hb; KSR; KSR1; RSU2
UniProt ID: (Human) Q8IVT5, (Mouse) Q61097
Entrez Gene ID: (Human) 8844, (Mouse) 16706, (Rat) 360573
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP-kinase scaffold activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
metal ion binding
14-3-3 protein binding
protein serine kinase activity
protein C-terminus binding
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase binding
non-receptor serine/threonine protein kinase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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