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Invitrogen
KIF3A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-121019
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 430-699 of human KIF3A (NP_008985.3).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.38 mg/mL
Amount
238 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: MCF-7, SW480, 293T, SKOV3, HeLa, Mouse brain, Mouse ovary, Rat liver, Rat brain. The target is usually found in the following locations: Cell projection, Cytoplasm, cilium, cytoskeleton.
Immunogen sequence: RKALETKLDM EEEERNKARA ELEKREKDLL KAQQEHQSLL EKLSALEKKV IVGGVDLLAK AEEQEKLLEE SNMELEERRK RAEQLRRELE EKEQERLDIE EKYTSLQEEA QGKTKKLKKV WTMLMAAKSE MADLQQEHQR EIEGLLENIR QLSRELRLQM LIIDNFIPRD YQEMIENYVH WNEDIGEWQL KCVAYTGNNM RKQTPVPDKK EKDPFEVDLS HVYLAYTEES LRQSLMKLER PRTSKGKARP KTGRRKRSAK PETVIDSLLQ
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kinesin family protein 3A; kinesin-II subunit; microtubule plus end-directed kinesin motor 3A; microtubule-based motor; N-4 kinesin; unnamed protein product
Gene Aliases: FLA10; Kif3; Kifl; KLP-20; Kns3
UniProt ID: (Human) Q9Y496, (Mouse) P28741
Entrez Gene ID: (Human) 11127, (Mouse) 16568, (Rat) 84392
microtubule motor activity
protein binding
ATP binding
microtubule binding
cytoskeletal protein binding
ATP-dependent microtubule motor activity, plus-end-directed
ATPase activity
protein phosphatase binding
spectrin binding
small GTPase binding
macromolecular complex binding
kinesin binding
intraciliary transport particle B binding
nucleotide binding
motor activity
in utero embryonic development
kidney development
heart looping
cilium movement
microtubule-based movement
smoothened signaling pathway
determination of left/right symmetry
heart development
anterograde axonal transport
epidermis development
anterior/posterior pattern specification
dorsal/ventral pattern formation
centriole-centriole cohesion
transport along microtubule
protein transport
dentate gyrus development
dorsal/ventral neural tube patterning
neural tube development
forebrain development
microtubule anchoring at centrosome
epidermal stem cell homeostasis
motile cilium assembly
positive regulation of smoothened signaling pathway
positive regulation of receptor-mediated endocytosis
positive regulation of epithelial cell proliferation
inner ear receptor stereocilium organization
cilium morphogenesis
neural precursor cell proliferation
alpha-tubulin acetylation
positive regulation of intracellular protein transport
protein localization to nonmotile primary cilium
anterograde dendritic transport
anterograde dendritic transport of neurotransmitter receptor complex
protein localization to cell junction
positive regulation of axo-dendritic protein transport
non-motile cilium assembly
positive regulation of establishment or maintenance of cell polarity regulating cell shape
organelle organization
plus-end-directed vesicle transport along microtubule
response to silicon dioxide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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