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Invitrogen
CBLC Polyclonal Antibody
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FIGURE: 1 / 1
CBLC Antibody (PA5-121138) in WB
Western blot analysis of CBLC in extracts of various cell lines. Samples were incubated with CBLC Polyclonal antibody (Product # PA5-121138) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-121138
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 245-474 of human CBLC (NP_036248.3).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: 293T, Raji, U-937, Mouse kidney.
Immunogen sequence: DEVQERLQAC RDKPGSYIFR PSCTRLGQWA IGYVSSDGSI LQTIPANKPL SQVLLEGQKD GFYLYPDGKT HNPDLTELGQ AEPQQRIHVS EEQLQLYWAM DSTFELCKIC AESNKDVKIE PCGHLLCSCC LAAWQHSDSQ TCPFCRCEIK GWEAVSIYQF HGQATAEDSG NSSDQEGREL ELGQVPLSAP PLPPRPDLPP RKPRNAQPKV RLLKGNSPPA ALGPQDPAPA
Target Information
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cbl proto-oncogene C, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase C; CBL-3; E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Gene Aliases: 2310076I21Rik; 2310079L19Rik; CBL-3; CBL-SL; CBL3; CBLC; RNF57
UniProt ID: (Human) Q9ULV8, (Mouse) Q80XL1
Entrez Gene ID: (Human) 23624, (Mouse) 80794
phosphotyrosine binding
ubiquitin-protein transferase activity
epidermal growth factor receptor binding
calcium ion binding
protein binding
zinc ion binding
transferase activity
SH3 domain binding
receptor tyrosine kinase binding
metal ion binding
ubiquitin protein ligase activity
signal transducer activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ligase
metabolite interconversion enzyme
ubiquitin-dependent protein catabolic process
signal transduction
cell surface receptor signaling pathway
protein ubiquitination
regulation of signaling
protein catabolic process
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of MAPK cascade
negative regulation of neuron apoptotic process
protein stabilization
response to glial cell derived neurotrophic factor
negative regulation of epidermal growth factor-activated receptor activity
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of MAP kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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