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Invitrogen
Histone Macro-H2A.1 Polyclonal Antibody
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FIGURE: 1 / 7
Histone Macro-H2A.1 Antibody (PA5-121910) in IHC (P)
Immunohistochemistry analysis of Histone H2A.Y in paraffin-embedded Human Pancreatic cancer tissue. Samples were incubated with polyclonal antibody (Product # PA5-119169) at a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-121910
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein H2A Histone Family, Member Y. The antigen corresponds to amino acid range 109-369 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Core histone macro-H2A.1; H2A histone family member Y; H2A/y; Histone H2A.y; Histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; Medulloblastoma antigen MU-MB-50.205; unnamed protein product
Gene Aliases: H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1; MACROH2A1.1; macroH2A1.2; mH2A1
UniProt ID: (Human) O75367
Entrez Gene ID: (Human) 9555
rDNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
protein binding
double-stranded methylated DNA binding
enzyme binding
protein kinase binding
protein serine/threonine kinase inhibitor activity
structural constituent of chromatin
chromatin DNA binding
nucleosomal DNA binding
protein heterodimerization activity
ADP-D-ribose binding
ADP-D-ribose modification-dependent protein binding
poly-ADP-D-ribose modification-dependent protein binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
regulation of oxidative phosphorylation
DNA repair
chromatin organization
nucleosome assembly
dosage compensation by inactivation of X chromosome
regulation of lipid metabolic process
heterochromatin assembly
positive regulation of maintenance of mitotic sister chromatid cohesion
regulation of gene expression, epigenetic
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
regulation of chromatin silencing at rDNA
protein poly-ADP-ribosylation
establishment of protein localization to chromatin
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
regulation of NAD metabolic process
negative regulation of cell cycle G2/M phase transition
regulation of response to oxidative stress
negative regulation of response to oxidative stress
positive regulation of response to oxidative stress
positive regulation of endodermal cell differentiation
negative regulation of protein localization to chromosome, telomeric region
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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