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Invitrogen
Phospho-beta-2 Adrenergic Receptor (Ser261) Polyclonal Antibody
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Phospho-beta-2 Adrenergic Receptor (Ser261) Antibody (PA5-12977) in DB
Dot blot analysis of Phospho-beta-2 Adrenergic Receptor (Ser261). Samples were incubated with Phospho-beta-2 Adrenergic Receptor (Ser261) polyclonal antibody (Product # PA5-12977) using a dilution of 0.5 µg/mL. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed on nitrocellulose membrane.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-12977
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S261 of human ADRB2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.35 mg/mL
Amount
140 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; AR beta2; beta-2 adrenoceptor; beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286; putative; unnamed protein product
Gene Aliases: ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR
UniProt ID: (Human) P07550
Entrez Gene ID: (Human) 154
beta-amyloid binding
G-protein coupled receptor activity
adrenergic receptor activity
beta-adrenergic receptor activity
beta2-adrenergic receptor activity
protein binding
adenylate cyclase binding
potassium channel regulator activity
enzyme binding
identical protein binding
protein homodimerization activity
macromolecular complex binding
norepinephrine binding
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
receptor-mediated endocytosis
regulation of smooth muscle contraction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
endosome to lysosome transport
positive regulation of cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
positive regulation of MAPK cascade
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of mini excitatory postsynaptic potential
adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
regulation of blood vessel diameter
AMPA selective glutamate receptor signaling pathway
positive regulation of cardiac muscle cell contraction
positive regulation of cold-induced thermogenesis
positive regulation of glutamate receptor signaling pathway
positive regulation of autophagosome maturation
positive regulation of lipophagy
cellular response to beta-amyloid
response to psychosocial stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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