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Invitrogen
GCN2 Polyclonal Antibody
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FIGURE: 1 / 2
GCN2 Antibody (PA5-13924) in IHC (P)
Immunohistochemistry analysis of GCN2 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with GCN2 polyclonal antibody (Product # PA5-13924) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Product Details
PA5-13924
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCN2
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
160 µg
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; unnamed protein product
Gene Aliases: EIF2AK4; GCN2; KIAA1338; PVOD2
UniProt ID: (Human) Q9P2K8
Entrez Gene ID: (Human) 440275
DNA damage checkpoint
positive regulation of defense response to virus by host
adaptive immune response
T cell activation involved in immune response
immune system process
positive regulation of adaptive immune response
translational initiation
regulation of translation
regulation of translational initiation
protein phosphorylation
nervous system development
learning
long-term memory
regulation of translational initiation by eIF2 alpha phosphorylation
viral translation
negative regulation of translational initiation in response to stress
negative regulation of CREB transcription factor activity
cellular response to amino acid starvation
cellular response to UV
response to endoplasmic reticulum stress
negative regulation by host of viral genome replication
negative regulation of neuron differentiation
negative regulation of translational initiation
protein autophosphorylation
defense response to virus
regulation of cell cycle
regulation of feeding behavior
cellular response to cold
positive regulation of translational initiation in response to starvation
GCN2-mediated signaling
positive regulation of long-term synaptic potentiation
neuron projection extension
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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