Search
Invitrogen
p38 MAPK beta Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
p38 MAPK beta Antibody (PA5-14050) in IHC (P)
Immunohistochemistry analysis of p38 MAPK beta in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with p38 MAPK beta polyclonal antibody (Product # PA5-14050) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carc... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-14050
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 334-366 amino acids from the center region of human MAPK11
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP kinase 11; MAP kinase p38 beta; MAP kinase p38-2; MAPK 11; MAPK11; mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; protein kinase, mitogen activated kinase, 11, p38beta; splicing isoform of p38Beta MAP Kinase; stress-activated protein kinase-2; stress-activated protein kinase-2b; unnamed protein product
Gene Aliases: p38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
UniProt ID: (Human) Q15759, (Mouse) Q9WUI1
Entrez Gene ID: (Human) 5600, (Mouse) 19094
MAPK cascade
osteoblast differentiation
positive regulation of gene expression
stress-activated protein kinase signaling cascade
positive regulation of interleukin-12 production
intracellular signal transduction
p38MAPK cascade
positive regulation of erythrocyte differentiation
positive regulation of muscle cell differentiation
stress-activated MAPK cascade
bone development
cellular response to interleukin-1
cellular response to UV-B
cellular senescence
cellular response to virus
protein phosphorylation
protein maturation
regulation of cardiac muscle cell proliferation
negative regulation of cardiac muscle cell proliferation
pyroptosis
NLRP1 inflammasome complex assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support