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Invitrogen
NGFR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-142808
Product Specifications
Species Reactivity
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-PEGSDSTAPSTQEP (aa 202-215).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize the extracellular domain of p75NTR.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD271 antigen; gp80-LNGFR; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor p75NGFR; low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 ntr; TNR16; unnamed protein product
Gene Aliases: LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16
UniProt ID: (Rat) P07174
Entrez Gene ID: (Rat) 24596
beta-amyloid binding
death receptor activity
neurotrophin TRKA receptor binding
protein binding
calmodulin binding
coreceptor activity
small GTPase binding
ubiquitin protein ligase binding
identical protein binding
neurotrophin binding
macromolecular complex binding
nerve growth factor binding
preprotein binding
cellular glucose homeostasis
intracellular protein transport
signal transduction
Rho protein signal transduction
spermatogenesis
axon guidance
central nervous system development
circadian rhythm
regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
detection of temperature stimulus
negative regulation of angiogenesis
nerve development
negative regulation of cell migration
hair follicle morphogenesis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
dorsal aorta development
skeletal muscle cell differentiation
negative regulation of fibroblast growth factor receptor signaling pathway
regulation of cell proliferation
positive regulation of odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
skin development
response to ethanol
positive regulation of neuron differentiation
positive regulation of fibroblast proliferation
neuron apoptotic process
negative regulation of hair follicle development
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
negative regulation of dendritic spine development
extrinsic apoptotic signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of protein localization to nucleus
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
cellular response to beta-amyloid
positive regulation of neural precursor cell proliferation
positive regulation of endothelial cell apoptotic process
regulation of reactive oxygen species metabolic process
positive regulation of excitatory postsynaptic potential
positive regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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