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Invitrogen
CDK9 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-143306
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-KGSQITQQSTNQSRN.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell division protein kinase 9; cyclin dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; unnamed protein product
Gene Aliases: PITALRE
UniProt ID: (Mouse) Q99J95
Entrez Gene ID: (Mouse) 107951
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription coactivator binding
DNA binding
chromatin binding
obsolete transcription elongation regulator activity
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
snRNA binding
protein kinase binding
7SK snRNA binding
protein serine kinase activity
histone H1-4S187 kinase activity
regulation of DNA repair
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein phosphorylation
positive regulation of cardiac muscle hypertrophy
replication fork processing
regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
positive regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of muscle cell differentiation
nucleus localization
regulation of cell cycle
cellular response to cytokine stimulus
negative regulation of protein localization to chromatin
positive regulation of protein localization to chromatin
transcription elongation-coupled chromatin remodeling
transcription pausing by RNA polymerase II
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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