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Invitrogen

Ankyrin G Polyclonal Antibody

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Ankyrin G Polyclonal Antibody

Product Details

PA5-143526

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000-1:2,000
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Non-human primate, Rat

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

The C-terminal 398 amino acids of human ankyrin 3 expressed in and purified from E. coli
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

500 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942755

Target Information

Ankyrin-G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin-G is also found at sites of epithelial cell-cell contact and in the intracellular membranes of some cells. Ankyrin-G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin-G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANK-3; ankyrin 3 (G); ankyrin 3, epithelial; ankyrin 3, node of Ranvier (ankyrin G); ankyrin-G; brain-specific ankyrin-G; cytoskeletal protein; unnamed protein product

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Gene Aliases: 2900054D09Rik; ANK-3; AnkG; Ankyrin-3; ANKYRIN-G; MRT37

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UniProt ID: (Human) Q12955, (Mouse) G5E8K5, (Rat) O70511

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Entrez Gene ID: (Human) 288, (Bovine) 511203, (Mouse) 11735, (Rat) 361833

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Function(s)
structural constituent of cytoskeleton protein binding cytoskeletal protein binding cytoskeletal adaptor activity sodium channel regulator activity spectrin binding protein binding, bridging ion channel binding cadherin binding channel activator activity phosphorylation-dependent protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding
Process(es)
mitotic cytokinesis plasma membrane organization cytoskeleton organization signal transduction axonogenesis neuromuscular junction development positive regulation of gene expression positive regulation of cell communication by electrical coupling positive regulation of sodium ion transport magnesium ion homeostasis neuronal action potential positive regulation of homotypic cell-cell adhesion Golgi to plasma membrane protein transport regulation of potassium ion transport establishment of protein localization positive regulation of membrane potential Golgi vesicle transport cellular response to magnesium ion membrane assembly protein localization to plasma membrane maintenance of protein location in plasma membrane positive regulation of protein targeting to membrane protein localization to axon positive regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of delayed rectifier potassium channel activity axon guidance anterograde axonal transport establishment or maintenance of microtubule cytoskeleton polarity maintenance of protein location in cell clustering of voltage-gated sodium channels positive regulation of action potential negative regulation of endocytosis synapse organization axon development inorganic ion homeostasis regulation of action potential regulation of modification of postsynaptic structure positive regulation of NIK/NF-kappaB signaling regulation of protein targeting positive regulation of sodium ion import across plasma membrane regulation of cation transmembrane transport regulation of transcription from RNA polymerase II promoter response to immobilization stress
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