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Invitrogen

Phospho-MYH9 (Ser1916) Polyclonal Antibody

View all (37) MYH9 antibodies

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Product Details

PA5-143719

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Phospho-Myosin IIA Heavy Chain (Ser-1916) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Ser-1916 in human myosin IIA heavy chain. This peptide sequence is highly conserved in rat and mouse myosin IIA heavy chain.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

~1.0 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942947

Product Specific Information

This antibody was cross-adsorbed to unphosphorylated Myosin IIA Heavy Chain (Ser-1916) peptide before affinity purification using phospho-Myosin IIA Heavy Chain (Ser-1916) peptide (without carrier). The antibody detects a 200 kDa* protein corresponding to Myosin IIA Heavy Chain on SDS-PAGE immunoblots of human A431 cells treated with Calyculin A. This reactivity is removed after treatment with lambda phosphatase.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes. Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids. This protein is a part of a hexameric complex, which includes two heavy chains, two regulatory light chains, and two essential light chains. The NMHC IIA protein interacts with actin filaments and is involved in cellular activities such as cell migration, adhesion, division, and maintenance of cell shape. Functionally, mutations in MYH9 can result in a spectrum of autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), which include conditions such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These disorders are primarily characterized by macrothrombocytopenia (abnormally large platelets) and may lead to other complications such as hearing loss, renal failure, and cataracts later in life. MYH9 is also crucial in hematopoiesis, where its proper function is necessary for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cellular myosin heavy chain, type A; flectin; MGC104539; motor protein; MYH9; Myosin heavy chain 9; myosin heavy chain IX; Myosin heavy chain, non-muscle IIa; myosin IIA; myosin, heavy chain 9, non-muscle; Myosin-9; myosin-9-like; myosin9; NMHC II-A; NMHC-II A; NMMHC II-a; NMMHC IIA; NMMHC-A; non-muscle myosin heavy chain 9; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain (NMHC); nonmuscle myosin heavy chain II-A; nonmuscle myosin IIA2; unnamed protein product

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Gene Aliases: BDPLT6; DFNA17; EPSTS; Fltn; FTNS; MATINS; MHA; MYH9; Myhn-1; Myhn1; NMHC-II-A; NMHCIIA; NMMHC-A; NMMHC-IIA; NMMHCA; TU72.6

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UniProt ID: (Human) P35579, (Mouse) Q8VDD5

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Entrez Gene ID: (Rat) 100911597, (Human) 4627, (Mouse) 17886

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Function(s)
microfilament motor activity motor activity actin binding ATP binding ATPase activity actin-dependent ATPase activity protein homodimerization activity protein anchor ADP binding poly(A) RNA binding actin filament binding nucleotide binding virus receptor activity RNA binding integrin binding protein binding calmodulin binding protein domain specific binding identical protein binding cadherin binding
Process(es)
meiotic spindle organization cell morphogenesis involved in differentiation cytokinesis angiogenesis in utero embryonic development establishment of T cell polarity membrane protein ectodomain proteolysis phagocytosis, engulfment movement of cell or subcellular component cell adhesion myoblast fusion regulation of cell shape protein transport single organismal cell-cell adhesion actin filament polymerization actin filament-based movement platelet formation actomyosin structure organization actin cytoskeleton reorganization uropod organization blood vessel endothelial cell migration establishment of meiotic spindle localization actin filament capping platelet aggregation negative regulation of actin filament severing positive regulation of protein processing in phagocytic vesicle metabolic process monocyte differentiation cell morphogenesis plasma membrane repair cytoskeleton organization integrin-mediated signaling pathway actin cytoskeleton organization lysosome localization cytokinetic process regulation of actin filament-based process endodermal cell differentiation regulated exocytosis viral entry into host cell cell motility leukocyte migration cytoplasmic actin-based contraction involved in cell motility cortical granule exocytosis cell-cell adhesion regulation of plasma membrane repair
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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