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Invitrogen
EphA6 Polyclonal Antibody
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FIGURE: 1 / 3
EphA6 Antibody (PA5-14584) in IHC (P)
Immunohistochemistry analysis of EphA6 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with EphA6 polyclonal antibody (Product # PA5-14584) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-14584
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1006-1035 amino acids from the C-terminal region of human Eph Receptor A6
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
EPHA6 is a member of the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in axon guidance, neuron-target interactions, regional compartmentalization, and synaptic functions in nervous systems. EPHA6 is highly expressed in the brain and testis. Reduction in EPHA6 has been detected in Hypospadias, a common defect affecting the growth and closure of the external genitalia. Genetic inhibition of EPHA6 in mice produces behavioral deficits specifically in tests of learning and memory. Mice deficient in EPHA6 show reduced memory of the consequences of the training context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp434C1418; EHK-2; EK12; EPH homology kinase 2; EPH-like kinase 12; ephrin receptor EphA6; Ephrin type-A receptor 6; FLJ35246; unnamed protein product
Gene Aliases: EHK-2; EHK2; EK12; EPA6; EPHA6; HEK12; m-ehk2; PRO57066
UniProt ID: (Human) Q9UF33
Entrez Gene ID: (Human) 285220, (Mouse) 13840
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
transmembrane-ephrin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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