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Invitrogen
NTF3 Polyclonal Antibody
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FIGURE: 1 / 8
NTF3 Antibody (PA5-14861) in WB
Western blot analysis of NTF3 in various lysates. Samples were incubated with NTF3 polyclonal antibody (Product # PA5-14861) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Human ovary lysate; Lane 2: Human spleen lysate. Predicted band size: 29 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-14861
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 152-184 amino acids from the C-terminal region of human NTF3
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, chicken, porcine, rat and Xenopus based on sequence homology.
Target Information
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; neurotrophin-3 (HDNF/NT-3); NGF-2; NT-3; NTF3; unnamed protein product
Gene Aliases: AI316846; AI835689; HDNF; NGF-2; NGF2; NT-3; NT3; Ntf-3; NTF3
UniProt ID: (Human) P20783, (Mouse) P20181, (Rat) P18280
Entrez Gene ID: (Human) 4908, (Mouse) 18205, (Rat) 81737
positive regulation of receptor internalization
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell-cell signaling
nervous system development
positive regulation of cell proliferation
nerve development
positive regulation of cell migration
nerve growth factor signaling pathway
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
neuron projection morphogenesis
modulation of synaptic transmission
positive chemotaxis
induction of positive chemotaxis
positive regulation of protein kinase B signaling
activation of MAPK activity
neuromuscular synaptic transmission
glial cell fate determination
axon guidance
brain development
peripheral nervous system development
epidermis development
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
mechanoreceptor differentiation
myelination
regulation of neuron apoptotic process
regulation of neuron differentiation
positive regulation of glial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
enteric nervous system development
neuron development
generation of neurons
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
smooth muscle cell differentiation
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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