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Invitrogen
LRP1 Cluster III Polyclonal Antibody
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Product Details
PA5-148911
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Chinese hamster ovary cell line CHO-derived human LRP-1 Cluster III, Ser2522-Ile2941
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Cluster III is a specific domain within the LRP1 gene, which encodes a large endocytic receptor involved in various physiological processes, including lipid metabolism, signal transduction, and cellular homeostasis. LRP1 is a multifunctional receptor that binds and internalizes a wide range of ligands, including lipoproteins, proteases, and extracellular matrix proteins. Cluster III of LRP1 is one of its four ligand-binding domains and plays a crucial role in mediating interactions with specific ligands, thereby influencing receptor function. This domain is important for the clearance of amyloid-beta in the brain, which is relevant to Alzheimer's disease, as well as for the regulation of protease activity and the modulation of cell signaling pathways that impact cell migration, proliferation, and survival. Dysregulation or mutations in LRP1, including its Cluster III domain, have been implicated in various diseases, such as cardiovascular disorders, neurodegenerative diseases, and certain cancers. Understanding the structure and function of LRP1 Cluster III is essential for developing targeted therapeutic strategies aimed at modulating its activity to treat related diseases. Research into LRP1 Cluster III provides valuable insights into the receptor's diverse roles in health and disease and its potential as a therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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