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Invitrogen
EDG2 Polyclonal Antibody
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Product Details
PA5-149501
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human LPAR-1 CD33 protein containing the sequences for the four extracellular domains, amino acids (aa) 1-50, aa112-125, aa190-205 and aa281-294
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDG2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; unnamed protein product; ventricular zone gene 1
Gene Aliases: edg-2; EDG2; Gpcr26; LPA1; LPAR1; Mrec1.3; rec.1.3; vzg-1; VZG1
UniProt ID: (Human) Q92633
Entrez Gene ID: (Human) 1902
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
negative regulation of neuron projection development
oligodendrocyte development
cerebellum development
optic nerve development
neurogenesis
corpus callosum development
bleb assembly
positive regulation of Rho protein signal transduction
myelination
Golgi to plasma membrane protein transport
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cilium assembly
positive regulation of stress fiber assembly
cell chemotaxis
regulation of vesicle-mediated transport
positive regulation of dendritic spine development
protein localization to cilium
cellular response to oxygen levels
positive regulation of smooth muscle cell chemotaxis
regulation of synaptic vesicle cycle
regulation of postsynaptic neurotransmitter receptor internalization
negative regulation of cAMP/PKA signal transduction
negative regulation of cilium assembly
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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