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The LCN5 gene, a member of the lipocalin family, encodes a protein implicated in sperm maturation and fertilization, particularly in the caput epididymidis. The gene's promoter region has been harnessed to study gene expression in specific tissues using a Cre/loxP system, illustrating its tissuespecific functionality. Located on the mouse genome, the LCN5 gene appears strategically positioned alongside several other lipocalin genes, indicating a possible evolutionary adaptation related to reproductive physiology. Lipocalins generally serve as transporters for small hydrophobic molecules and are involved in various physiological processes, including immune response modulation and cell communication. Although not directly associated with the CLCN5 gene involved in Dent disease, understanding the broader lipocalin family provides valuable insights into their diverse biological roles, including those related to cardiovascular health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Chloride channel protein 5; Chloride transporter ClC-5; ClC-5; E-RABP; H(+)/Cl(-) exchange transporter 5; LCN5; mE-RABP; MEP10
Gene Aliases: 5430408K11Rik; ClC-5; Clc5; Clcn5; D930009B12Rik; DXImx42e; Sfc13; T25545
UniProt ID: (Mouse) Q9WVD4
Entrez Gene ID: (Mouse) 12728
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