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Invitrogen
GAK Polyclonal Antibody
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FIGURE: 1 / 3
GAK Antibody (PA5-15321) in IHC (P)
Immunohistochemistry analysis of GAK in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with GAK polyclonal antibody (Product # PA5-15321) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatoca... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-15321
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1140-1170 amino acids from the C-terminal region of human GAK
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: auxilin-2; dnaJ homolog subfamily C member 26; unnamed protein product
Gene Aliases: D130045N16Rik; DNAJ26; DNAJC26
UniProt ID: (Human) O14976, (Mouse) Q99KY4
Entrez Gene ID: (Human) 2580, (Mouse) 231580
protein folding
receptor-mediated endocytosis
endoplasmic reticulum organization
Golgi organization
negative regulation of neuron projection development
synaptic vesicle uncoating
protein localization to Golgi apparatus
clathrin coat assembly
clathrin coat disassembly
clathrin-mediated endocytosis
protein localization to plasma membrane
Golgi to lysosome transport
regulation of clathrin coat assembly
epidermal cell differentiation
intrahepatic bile duct development
cell development
forebrain morphogenesis
establishment of skin barrier
positive regulation of neural precursor cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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